亚博拜仁合作伙伴

地点：亚博拜仁合作伙伴D楼312室

时间：2019.5.23星期四 下午1：45

报告人：侯仰龙教授 （北京大学工学院）

报告题目与内容

Fabrication and Multifunctional Applications of Magnetic Nanomaterials

Yanglong Hou

Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKLMMD), Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT), Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China

Magnetic nanomaterials (MNMs) have attracted significant interest in the past few decades due to their unique properties such as superparamagnetism, which results from the influence of thermal energy on a ferromagnetic nanoparticle. To understand the fundamental behavior of nanomagnetism and develop relevant potential applications, various preparation routes have been explored to produce MNMs with desired properties and structures, among which chemical synthesis, especially high-temperature organic-phase method, play an indispensable role in which the microstructures and physical/chemical properties of MNMs can be tuned by controlling the reaction conditions such as precursor, surfactant, or solvent amounts, reaction temperature or time, reaction atmosphere, etc. In this talk, we first introduce the fundamental of high-temperature organic-phase method, and present the progress on the synthesis of plenty of MNMs, including monocomponent nanostructures (like metals, metal alloys, metal oxides/carbides) and multicomponent nanostructures (heterostructures and exchange-coupled nanomagnets). Considering the latter type not only retain the functionalities from each single component, but also possess synergistic properties that emerge from interfacial coupling, with improved magnetic, optical or catalytic features, and therefore, we will discuss the potential applications of MNMs in biomedicine and catalysis. For an instance, Fe5C2, one kind of representative iron carbide, have shown infinite possibilities. It showed intrinsic catalytic properties during Fischer−Tropsch synthesis, no matter in efficiency and selectivity. On the other hand, through modification of affinity proteins (ZHER2:342), Fe5C2 NPs can selectively bind to HER2 overexpressing cancer cells. T2-weighted MRI and PAT signals are readily observed, and tumors are effectively ablated by PTT under NIR irradiation. To enhance cancer therapeutic efficiency, anticancer drug doxorubicin is loaded into bovine serum albumin coated Fe5C2 NPs, combining PTT with chemotherapy. Such nanoplatform can respond to NIR and acidic environments, and exhibit burst drug release. In summary, we overview the rational design, fabrications of magnetic nanomaterials, this kind of materials give great application potential in biomedicine and nanocatalysis.

Keywords: Magnetic nanostructures, Synthesis, Therapy, MRI, PTT

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报告人简介：